The focus of the project is on elucidating neuronal mechanisms of energy efficient signaling in human cortical neurons. A critical requirement of fast neuronal computation and better cognitive function is the ability of neurons to generate and maintain fast and stable output - action potentials. Because of difficult access to living human neurons, their function in supporting cognition remains largely unexplored. Our lab has extensive experience in studying the function of human neurons from neurosurgery patients. We recently showed that fast action potential signaling in human neurons directly links to cognitive ability in the same individuals. The project will focus on human cortical neuron types that are selectively vulnerable in diseases of cognitive decline, such as Alzheimer’s disease (AD) and Frontotemporal dementia (FTD), since these neuron types show surprisingly fast signaling. In this project we will address the question of how these human-specialized neurons achieve fast synaptic and cellular signaling and how mechanisms of energy expenditure play a role, in both non-pathological and pathological conditions. The project is part of the Brainscapes consortium (https://brainscapes.nl) which offers and exciting environment for scientific interactions and collaborations.
Planned starting date for the project:
fall 2025
Your duties
During the research you will use the following approach:
As a university, we strive for equal opportunities for all, recognising that diversity takes many forms. We believe that diversity in all its complexity is invaluable for the quality of our teaching, research and service. We are always looking for talent with diverse backgrounds and experiences. This also means that we are committed to creating an inclusive community so that we can use diversity as an asset.
We realise that each individual brings a unique set of skills, expertise and mindset. Therefore we are happy to invite anyone who recognises themselves in the profile to apply, even if you do not meet all the requirements.
A challenging position in a socially engaged organisation. At VU Amsterdam, you contribute to education, research and service for a better world. And that is valuable. So in return for your efforts, we offer you:
We also offer you attractive fringe benefits and arrangements. Some examples:
Center for Neurogenomics and Cognitive Research (CNCR)
As of 2008, CNCR is the operational name of the Department of Neurosciences at the Faculty for Earth and Life Sciences (FALW, Vrije Universiteit). The CNCR is a vibrant scientific environment that generates integrated research programs from genes to behavior, each combining mouse and human studies (https://cncr.nl/). In our center, 150 people work closely together in defining how in essence simple molecular and cellular processes shape the emergent complexity of the brain.
We have the specific ambition to unravel the mechanisms by which brain cells and circuitry act both in health and disease. We aim to translate mechanistic knowledge into understanding of (dys)function of the human brain. Our neuroscience research area covers analysis over many spatial levels, from genes to the intact organism, and over a large temporal scale, from microsecond molecular events to the years of functioning of the human brain.
Faculty of Science
Researchers and students at VU Amsterdam’s Faculty of Science tackle fundamental and complex scientific problems to help pave the way for a sustainable and healthy future. From forest fires to big data, from obesity to malnutrition, and from molecules to the moon: we cover the full spectrum of the natural sciences. Our teaching and research have a strong experimentally technical, computational and interdisciplinary nature.
We work on new solutions guided by value-driven, interdisciplinary methodologies. We are committed to research, valorisation and training socially engaged citizens of the world who will make valuable contributions to a sustainable, healthy future.
Are you interested in joining the Faculty of Science? You will join undergraduate students, PhD candidates and researchers at the biggest sciences faculty in the Netherlands. You will combine a professional focus with a broad view of the world. We are proud of our collegial working climate, characterised by committed staff, a pragmatic attitude and engagement in the larger whole. The faculty is home to over 11,000 students enrolled in 40 study programmes. It employs over 1,600 professionals spread across 10 academic departments.
Vrije Universiteit Amsterdam
Vrije Universiteit Amsterdam stands for values-driven education and research. We are open-minded experts with the ability to think freely - a broader mind. Maintaining an entrepreneurial perspective and concentrating on diversity, significance and humanity, we work on sustainable solutions with social impact. By joining forces, across the boundaries of disciplines, we work towards a better world for people and planet. Together we create a safe and respectful working and study climate, and an inspiring environment for education and research. Learn more about our codes of conduct
We are located on one physical campus, in the heart of Amsterdam's Zuidas business district, with excellent location and accessibility. Over 6,150 staff work at the VU and over 31,000 students attend academic education.
Diversity
Diversity is the driving force of VU Amsterdam. VU wants to be accessible and receptive to diversity in disciplines, cultures, ideas, nationalities, beliefs, preferences and worldviews. We believe that trust, respect, interest and differences lead to new insights and innovation, to sharpness and clarity, to excellence and a broader understanding.
We stand for an inclusive community and believe that diversity and internationalisation contribute to the quality of education, research and our services.
Therefore, we are always searching for people whose backgrounds and experience contribute to the diversity of the VU community.
Are you interested in this position and do you believe that your experience will contribute to the further development of our university? In that case, we encourage you to submit your application before August 15, 2025.
Submitting a diploma and a reference check are part of the application process.
Applications received by e-mail will not be considered.
Acquisition in response to this advertisement is not appreciated.
The focus of the project is on elucidating neuronal mechanisms of energy efficient signaling in human cortical neurons. A critical requirement of fast neuronal computation and better cognitive function is the ability of neurons to generate and maintain fast and stable output - action potentials. Because of difficult access to living human neurons, their function in supporting cognition remains largely unexplored. Our lab has extensive experience in studying the function of human neurons from neurosurgery patients. We recently showed that fast action potential signaling in human neurons directly links to cognitive ability in the same individuals. The project will focus on human cortical neuron types that are selectively vulnerable in diseases of cognitive decline, such as Alzheimer’s disease (AD) and Frontotemporal dementia (FTD), since these neuron types show surprisingly fast signaling. In this project we will address the question of how these human-specialized neurons achieve fast synaptic and cellular signaling and how mechanisms of energy expenditure play a role, in both non-pathological and pathological conditions. The project is part of the Brainscapes consortium (https://brainscapes.nl) which offers and exciting environment for scientific interactions and collaborations.
Planned starting date for the project:
fall 2025
Your duties
During the research you will use the following approach:
As a university, we strive for equal opportunities for all, recognising that diversity takes many forms. We believe that diversity in all its complexity is invaluable for the quality of our teaching, research and service. We are always looking for talent with diverse backgrounds and experiences. This also means that we are committed to creating an inclusive community so that we can use diversity as an asset.
We realise that each individual brings a unique set of skills, expertise and mindset. Therefore we are happy to invite anyone who recognises themselves in the profile to apply, even if you do not meet all the requirements.
A challenging position in a socially engaged organisation. At VU Amsterdam, you contribute to education, research and service for a better world. And that is valuable. So in return for your efforts, we offer you:
We also offer you attractive fringe benefits and arrangements. Some examples:
Center for Neurogenomics and Cognitive Research (CNCR)
As of 2008, CNCR is the operational name of the Department of Neurosciences at the Faculty for Earth and Life Sciences (FALW, Vrije Universiteit). The CNCR is a vibrant scientific environment that generates integrated research programs from genes to behavior, each combining mouse and human studies (https://cncr.nl/). In our center, 150 people work closely together in defining how in essence simple molecular and cellular processes shape the emergent complexity of the brain.
We have the specific ambition to unravel the mechanisms by which brain cells and circuitry act both in health and disease. We aim to translate mechanistic knowledge into understanding of (dys)function of the human brain. Our neuroscience research area covers analysis over many spatial levels, from genes to the intact organism, and over a large temporal scale, from microsecond molecular events to the years of functioning of the human brain.
Faculty of Science
Researchers and students at VU Amsterdam’s Faculty of Science tackle fundamental and complex scientific problems to help pave the way for a sustainable and healthy future. From forest fires to big data, from obesity to malnutrition, and from molecules to the moon: we cover the full spectrum of the natural sciences. Our teaching and research have a strong experimentally technical, computational and interdisciplinary nature.
We work on new solutions guided by value-driven, interdisciplinary methodologies. We are committed to research, valorisation and training socially engaged citizens of the world who will make valuable contributions to a sustainable, healthy future.
Are you interested in joining the Faculty of Science? You will join undergraduate students, PhD candidates and researchers at the biggest sciences faculty in the Netherlands. You will combine a professional focus with a broad view of the world. We are proud of our collegial working climate, characterised by committed staff, a pragmatic attitude and engagement in the larger whole. The faculty is home to over 11,000 students enrolled in 40 study programmes. It employs over 1,600 professionals spread across 10 academic departments.
Vrije Universiteit Amsterdam
Vrije Universiteit Amsterdam stands for values-driven education and research. We are open-minded experts with the ability to think freely - a broader mind. Maintaining an entrepreneurial perspective and concentrating on diversity, significance and humanity, we work on sustainable solutions with social impact. By joining forces, across the boundaries of disciplines, we work towards a better world for people and planet. Together we create a safe and respectful working and study climate, and an inspiring environment for education and research. Learn more about our codes of conduct
We are located on one physical campus, in the heart of Amsterdam's Zuidas business district, with excellent location and accessibility. Over 6,150 staff work at the VU and over 31,000 students attend academic education.
Diversity
Diversity is the driving force of VU Amsterdam. VU wants to be accessible and receptive to diversity in disciplines, cultures, ideas, nationalities, beliefs, preferences and worldviews. We believe that trust, respect, interest and differences lead to new insights and innovation, to sharpness and clarity, to excellence and a broader understanding.
We stand for an inclusive community and believe that diversity and internationalisation contribute to the quality of education, research and our services.
Therefore, we are always searching for people whose backgrounds and experience contribute to the diversity of the VU community.
Are you interested in this position and do you believe that your experience will contribute to the further development of our university? In that case, we encourage you to submit your application before August 15, 2025.
Submitting a diploma and a reference check are part of the application process.
Applications received by e-mail will not be considered.
Acquisition in response to this advertisement is not appreciated.
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